CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke

BCV Campbell; L Weir; PM Desmond; HTH Tu; PJ Hand; B Yan; GA Donnan; MW Parsons; SM Davis

Journal article

CT perfusion improves diagnostic accuracy and confidence in acute ischaemic stroke

BCV Campbell, L Weir, PM Desmond, HTH Tu, PJ Hand, B Yan, GA Donnan, MW Parsons, SM Davis

Journal of Neurology Neurosurgery and Psychiatry | BMJ PUBLISHING GROUP | Published : 2013

DOI: 10.1136/jnnp-2012-303752

Abstract

Background and objective: CT perfusion (CTP) is rapid and accessible for emergency ischaemic stroke diagnosis. The feasibility of introducing CTP and diagnostic accuracy versus non-contrast CT (NCCT) in a tertiary hospital were assessed. Methods: All patients presenting <9 h from stroke onset or with wake-up stroke were eligible for CTP (Siemens 16-slice scanner, 2×24 mm slabs) unless they had estimated glomerular filtration rate (eGFR)<50 ml/ min or diabetes with unknown eGFR. NCCT was assessed by a radiologist and stroke neurologist for early ischaemic change and hyperdense arteries. CTP was assessed for prolonged time to peak and reduced cerebral blood flow. Technical adequacy was defined..

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University of Melbourne Researchers

Bruce Campbell Author

Patricia Desmond Author

Hans Tu Author

Bernard Yan Author

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Grants

Awarded by NHMRC of Australia

Funding Acknowledgements

BC receives research support from the NHMRC of Australia (postgraduate scholarship 567156, early career fellowship 1035688), the Heart Foundation of Australia, National Stroke Foundation, a Cardiovascular Lipid (CVL) Australia grant and the Neuroscience Foundation of the Royal Melbourne Hospital. Infrastructure support was received for these studies through the Victorian Government Operational Infrastructure Program to the Florey Institute of Neuroscience and Mental Health.